Synthesis, Characterization and Anticancer Evaluation of New Quinoline Derivatives from Meldrum Acid by Many Steps
Keywords:
Quinoline Derivatives, Anti Breast cancer, DMSO-d6, EtOH, Methylene Meldrum acid CompoundsAbstract
This research Included synthesis of new Quinoline Derivative from Methylene Meldrum acid (2L, 2M) Record previously by many steps. Starting Conversion the Phenylamine (methylene Meldrum's acid)derivatives to substitute quinolone(3L, 3M), then reacted it with POCl3 to give the substituted 4-chloro quinoline derivative (4L, 4M) that which containing free choro group that reaction with different boronic acids in the presence of Tetrakis (triphenylphosphine) palladium (0) gives the 4-phenylquinolines (5L, 5M). Then the study Anticancer Evaluation of some new compounds. the structure of these compounds were characterized by (H1-NMR, C13-NMR, H-HCOSY NMR, FT-IR) Techniques, melting points and other physical studies.
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