https://biotech.journalspub.info/?journal=JGER&page=issue&op=feedInternational Journal of Genetic Engineering and Recombination2023-02-22T04:01:53+00:00Akshita Sinhalifesciences.editor@stmjournals.comOpen Journal Systems<p align="center"><strong>International Journal of Genetic Engineering and Recombination </strong><strong>(IJGER)</strong><strong></strong></p><p align="center"> </p><p align="center"><strong>Click </strong><strong><a href="/?journal=JGER&page=about&op=editorialTeam">here</a> for complete Editorial Board</strong></p><p align="center"><strong> </strong></p><p><strong>International Journal of Genetic Engineering and Recombination <strong>(IJGER)</strong>: </strong>Journal provides a medium for rapid publication of research and review articles that are original and can create an immediate impact on the ongoing research. Journal includes site-specific recombination, recombination frequency, and recombination hotspots as the major topics. Articles included in the journal can be original research articles, review articles, or short communication. </p><p><strong>Journal DOI No: 10.37628/IJGER</strong></p><p><strong>Readership:</strong> Graduates, Postgraduates, Research Scholars, </p><p><strong>Indexing: </strong>The Journal is indexed in Google Scholar, Journal TOC</p><p><strong>Focus and Scope Cover</strong></p><p>• Gene patent</p><p>• Genetically modified crops</p><p>• Genetically modified food</p><p>• Genetically modified organisms</p><p>• Induced stem cells</p><p>• Marker-assisted selection</p><p>• Paratransgenesis</p><p>• Recombination frequency</p><p>• Recombination hotspot</p><p>• Four-gamete test</p><p>• Independent assortment</p><p>• Site-specific recombination</p><p>• Site-specific recombinase technology</p><p> </p><div id="journalDescription"><p><strong>Submission of Paper: </strong><strong></strong></p><p><strong> </strong></p><p>All contributions to the journal are rigorously refereed and are selected on the basis of the quality and originality of the work. The journal publishes the most significant new research papers or any other original contribution in the form of reviews and reports on new concepts in all areas pertaining to its scope and research being done in the world, thus ensuring its scientific priority and significance.</p><p> </p><p>Manuscripts are invited from academicians, students, research scholars, and faculties for publication consideration.</p><p> </p><p>Papers are accepted for editorial consideration through email <strong>info@journalspub.com </strong>or <strong>lifesciences.editor@stmjournals.com</strong><strong></strong></p><p> </p><p><strong>Abbreviation: IJGER</strong></p><p><em><br /></em><strong>Frequency</strong>: Two issues per year</p><p> </p><p><strong><a href="http://nursing.journalspub.info/index.php?journal=IJIN&page=about&op=editorialPolicies#peerReviewProcesshttp://nursing.journalspub.info/index.php?journal=IJIN&page=about&op=editorialPolicies">Peer-Reviewed Policy</a></strong><strong></strong></p><p align="center"><strong> </strong></p><p><strong><a href="http://journalspub.com/JournalsDetails.aspx?jid=87">Editorial Board</a></strong> </p><p> </p><p><a href="http://journalspub.com/pdf/Guidelines%20for%20authors.pdf"><strong>Instructions to Authors</strong></a></p></div><p> </p><div id="additionalHomeContent"><p><strong>Publisher:</strong> JournalsPub, an imprint of Dhruv Info Systems Private Limited</p><p><strong>Address:</strong> A-118, 2nd Floor, Sector-63, Noida, Uttar Pradesh-201301, India</p><p><strong>Phone no.:</strong> 0120-478-1235/ <strong>Email:</strong> lifesciences.editor@stmjournals.com</p><p><strong>Commissioning Editor: </strong>Akshita Sinha </p></div>https://biotech.journalspub.info/?journal=JGER&page=article&op=view&path%5B%5D=794Application of Vector Mediated Gene Therapy in the Field of Cancer Treatment2023-02-13T09:02:38+00:00Priyadarshi Mukherjeepriyadarshimukherjee78@gmail.comRitashree Bandyopadhyaypriyadarshimukherjee78@gmail.comAnshika Basakpriyadarshimukherjee78@gmail.com<p><em>The recent years have witnessed a remarkable development in the field of genetic modification. Having multifarious applications in the field of medical care, a similar improvement has been observed in cancer treatment, a field where gene therapy is improved quite frequently. Gene therapy involves transforming viruses to shuttles that transfer a modified gene to the target group of cells. Vectors used can be Retroviral, Adenoviral or Adeno-Associated viral vectors depending upon the gene expression size (large/small) and the duration of expression (long/short term). The most commonly used viruses for vectors are based on adenovirus and adeno-associated viruses. Although most of it is still in the clinical trial stage, we can say that the future possibilities are surely bright for this process. The efficacy can surely be improved, and in spite of the drawbacks, it is one of the more blooming fields in the arena of both genetic engineering and medical science, with significant promises for the future.</em></p>2022-11-12T09:07:08+00:00Copyright (c) 2022 International Journal of Genetic Engineering and Recombinationhttps://biotech.journalspub.info/?journal=JGER&page=article&op=view&path%5B%5D=808Chitin synthase gene regulation in fungal species-An Insight2023-02-13T09:02:38+00:00Kritika Guptakritikagupta45@gmail.comAkshita Angirishikritikagupta45@gmail.comRatnesh Jainkritikagupta45@gmail.comPrajakta Dandekarpd.jain@ictmumbai.edu.in<p><em>Chitin synthase (CHS) gene is imperative for the formation of chitin, a polymer of N-acetyl glucosamine units. Chitin is an important component of the fungal cell wall, wherein it maintains the cell morphology and is involved in immune response of the host plants. Chitin synthases are classified according to the genes responsible of their production and their diverse functions in different fungi. Chitin production, which majorly occurs in insects and fungi, can thus be regulated by controlling the transcription and translation of the chitin synthase gene. Chitin is deacylated to form chitosan, which is a more soluble and flexible polymer that has been explored for diverse industrial applications. The CHS gene performs different functions at specific stages of cell cycle and is regulated by various factors that affect chitin production. CHS gene can be regulated using chitin inhibitors and thus acts as a suitable target for therapeutic molecules against various fungal diseases. In this manuscript we have discussed the regulation of CHS gene via chitin inhibitors and its implications on the chitin synthesis pathway. Further, the role of this pathway in various in vitro antifungal studies and therapeutic applications has been elaborately discussed.</em></p>2022-12-14T05:11:47+00:00Copyright (c) 2022 International Journal of Genetic Engineering and Recombinationhttps://biotech.journalspub.info/?journal=JGER&page=article&op=view&path%5B%5D=830Communicative Skills of a Child with Fragile X Syndrome: A Case Report2023-02-13T09:02:38+00:00Girish. K. Sgirish06ks@gmail.comApoorva. K.Sgirish06ks@gmail.comHemalatha Lgirish06ks@gmail.com<p><em>Fragile X syndrome (FXS) is the most common form of X-linked disorder caused by mutations in the ‘Fragile X Messenger Ribonucleoprotein 1’ gene leading to intellectual, behavioral, social, and learning challenges. </em><em>Many early investigations evaluating the characteristics of FXS were not conducted by speech-language pathologists, and the characteristics in those earlier studies were not properly justified. </em><em>Hence the present study aimed to investigate and discuss the speech, language, cognitive, and social behavioral characteristics of a child diagnosed with fragile X syndrome. A 13-year-old male suffering from FXS with significant prenatal, postnatal, family, and developmental history reported to department of Speech-Language Pathology. Detailed evaluations revealed typical orofacial characteristics, oro-motor weakness, poor intellectual functioning, social behavioral problems, and conductive hearing loss.</em></p>2023-01-11T04:25:34+00:00Copyright (c) 2023 International Journal of Genetic Engineering and Recombinationhttps://biotech.journalspub.info/?journal=JGER&page=article&op=view&path%5B%5D=832Use of Black Soldier Fly (BSF) for the Treatment of the Cancer in Rat, Rattus norvegicus (L)2023-02-22T04:01:53+00:00Vitthalrao Bhimasha Khyadevbkhyade.2016@gmail.comRajkumar V. Bajolgevbkhyade.2016@gmail.comPratiksha Dhananjay Patilvbkhyade.2016@gmail.comNilam Dilip Waralevbkhyade.2016@gmail.com<p><em>The death-dealing cancer and the most frequent cancer in human population is the cancer of colon. Drug resistance capabilities and scarcity of effective drug are supposed to be the obstacles in the method of treatment for cancer of colon. The methanol solution (100 ppm) maceratives of pre-pupal stages of BSF Hermetia illucens (L.) and zingiberene (Terpene of “Monocyclic-Sesquiterpene” class), significant constituent of Zingiber officinale (L.) were assessed for treating the cells of cancer of the colon, belong to Norwegian rat, Rattus norvegicus (L). The cell counting assay was utilized for assessment of rate of proliferation of the cells of colon cancer. Autophagy was detected by using of transmission electron microscopy (TEM). The varied concentrations of monocyclic-sesquiterpene, zingiberene and the methanol maceratives of pre-pupal stages of BSF Hermetia illucens (L.) used for treating the “Transfected cells” derived from rat colon include: 100.00, 150.00 and 200.00 µl. The fluorescent microscopy was utilized for monitoring. The cell cycle was analysed using the flow cytometry. Expression of the protein was carried out through the immunoblotting. The zingiberene (Terpene of “Monocyclic-Sesquiterpene” class), significant constituent of Zingiber officinale (L.) and the methanol maceratives of pre-pupal stages of BSF Hermetia illucens (L.) were found considerably inhibiting the proliferation of cancer cells of colon from Norwegian rat, Rattus norvegicus (L). The zingiberene and the contents of the macceratives of BSF are responsible for the purpose to induce the autophagy in present attempt. This treatment may be responsible for inhibition of growth of cancer cells in the colon of Norwegian rat, Rattus norvegicus (L). The methanol maceratives of pre-pupal stages of BSF Hermetia illucens (L.) may be utilized for establishment of therapy to control the cancer of colon. </em></p>2023-02-13T08:57:05+00:00Copyright (c) 2023 International Journal of Genetic Engineering and Recombinationhttps://biotech.journalspub.info/?journal=JGER&page=article&op=view&path%5B%5D=835MONKEYPOX: A sudden sporadic outbreak!2023-02-13T09:02:39+00:00Aman Sharmasharmaaman1421@gmail.comSuparna Chakrabortysuparnachakraborty2020@gmail.comPulkit Gautampulkitgautam2@gmail.com<p class="Body"><em>There is increasing cases of Monkeypox infections in the already preoccupied period of COVID-19 pandemic. The sudden spread of the orthopox virus infection especially in non-African countries and different parts of the world at the same time with some of the patients having no travel history in potential hotspots of this disease is a matter of concern. It is similar to smallpox infection except for the occurrence of lymphadenopathy in Monkeypox infections. The range of species that the virus is being nurtured is not fully known yet, but rodents and primates are considered major potential reservoirs inhabiting Central and West Africa and the viral spread takes place in agricultural settlements and consumption of bush meat. Mortality rates vary between 1–11%, although among survivors, scarring and other aftereffects are frequent. Urgent surveillance strategies and worldwide vaccination strategies are needed to be implemented to avoid outbreaks similar to smallpox. </em><em></em></p>2023-01-23T04:48:39+00:00Copyright (c) 2023 International Journal of Genetic Engineering and Recombination