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Use of Black Soldier Fly (BSF) for the Treatment of the Cancer in Rat, Rattus norvegicus (L)
Abstract
The death-dealing cancer and the most frequent cancer in human population is the cancer of colon. Drug resistance capabilities and scarcity of effective drug are supposed to be the obstacles in the method of treatment for cancer of colon. The methanol solution (100 ppm) maceratives of pre-pupal stages of BSF Hermetia illucens (L.) and zingiberene (Terpene of “Monocyclic-Sesquiterpene” class), significant constituent of Zingiber officinale (L.) were assessed for treating the cells of cancer of the colon, belong to Norwegian rat, Rattus norvegicus (L). The cell counting assay was utilized for assessment of rate of proliferation of the cells of colon cancer. Autophagy was detected by using of transmission electron microscopy (TEM). The varied concentrations of monocyclic-sesquiterpene, zingiberene and the methanol maceratives of pre-pupal stages of BSF Hermetia illucens (L.) used for treating the “Transfected cells” derived from rat colon include: 100.00, 150.00 and 200.00 µl. The fluorescent microscopy was utilized for monitoring. The cell cycle was analysed using the flow cytometry. Expression of the protein was carried out through the immunoblotting. The zingiberene (Terpene of “Monocyclic-Sesquiterpene” class), significant constituent of Zingiber officinale (L.) and the methanol maceratives of pre-pupal stages of BSF Hermetia illucens (L.) were found considerably inhibiting the proliferation of cancer cells of colon from Norwegian rat, Rattus norvegicus (L). The zingiberene and the contents of the macceratives of BSF are responsible for the purpose to induce the autophagy in present attempt. This treatment may be responsible for inhibition of growth of cancer cells in the colon of Norwegian rat, Rattus norvegicus (L). The methanol maceratives of pre-pupal stages of BSF Hermetia illucens (L.) may be utilized for establishment of therapy to control the cancer of colon.
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DOI: https://doi.org/10.37628/ijger.v8i2.832
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