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Recombination, An Evolutionary Boon

Ishika Govil

Abstract


It is discussed the debate over the evolutionary advantage of recombination, which was first identified by FISHER and MULLER. Those whose models had finite-population effects benefited from recombination, whereas those whose models didn't possess finite-population effects didn't. No one discovered any of the models with unlimited populations. Recombination has the advantage of breaking down random linkage disequilibrium caused by mutations. Genetic drift is a term used to describe the process by which the typical impact of this randomly generated linkage disequilibrium, according to HILL and ROBERTSON, was for connected loci to interfere even where there was no gene interaction between the loci, with each other's response to selection The original effect is demonstrated to be identical to this one. FISHER and MULLER's counterargument the "ratchet mechanism" is predicted as well. MULLER was the one who discovered it, pointing out that detrimental mutations were more likely to be found without recombination, easily increase in a population Simulations on the computer of the long-term growth of harmful mutants and the substitution of favorable mutants. The core accuracy of the system was validated by mutations.


Keywords


Mutations, Segregation, Homologous sequences, Gene therapy, Recombination

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References


Felsenstein, J., 1974. The evolutionary advantage of recombination. Genetics, 78(2), pp.737-756.

Meselson, M.S. and Radding, C.M., 1975. A general model for genetic recombination. Proceedings of the National Academy of Sciences, 72(1), pp.358-361.

Kowalczykowski, S.C., 2000. Initiation of genetic recombination and recombination-dependent replication. Trends in biochemical sciences, 25(4), pp.156-165.

Renkawitz, J., Lademann, C.A. and Jentsch, S., 2014. Mechanisms and principles of homology search during recombination. Nature Reviews Molecular Cell Biology, 15(6), pp.369-383.

Wetzel, R., 1980. Applications of Recombinant DNA Technology: The new methods for precise manipulation of genetic material have made possible the transfer of genes between organisms, opening new avenues for basic and applied biochemical research. American scientist, 68(6), pp.664-675.

https://www.utsouthwestern.edu/edumedia/edufiles/education_training/programs/stars/holland-dnatech-history.pdf

Baxter, K., Edelen, T., Griswold, E., Hyland, K., MacKinlay, A., McManus, H., O'Quinn, R.,Taylor, D., Brown, E., Erickson, C. and Hall, J., News from the Society, the Sections and the Committees.

Richards, J. ed., 2012. Recombinant DNA: Science, ethics and politics. Elsevier.

Slavkin, H.C., 1996. And the next 50 years? The future of recombinant DNA technology in oral medicine. Journal of public health dentistry, 56(5), pp.278-285.

https://sciencing.com/pros-cons-recombinant-dna-technology 8433972.html

Alt, F.W., Oltz, E.M., Young, F., Gorman, J., Taccioli, G. and Chen, J., 1992. VDJ recombination. Immunology today, 13(8), pp.306-314.

Krogh, B.O. and Symington, L.S., 2004. Recombination proteins in yeast. Annu. Rev. Genet., 38,pp.233-271.

Kosambi, D.D., 2016. The estimation of map distances from recombination values. In DD Kosambi (pp. 125-130). Springer, New Delhi.

Umene, K., 1999. Mechanism and application of genetic recombination in herpesviruses. Reviews in medical virology, 9(3), pp.171-182.

Vergunst, A.C. and Hooykaas, P.J., 1999. Recombination in the plant genome and its application in biotechnology. Critical Reviews in Plant Sciences, 18(1), pp.1-31.


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