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MECHANISTIC TARGETING OF TNF-α AND NF-κB IN INFLAMMATORY DISEASES

Prerna Sharma, Hitesh Malhotra, Vandana Garg, Govind Singh, Aditya Ashri, Mohammad Amjad Kamal

Abstract


Rheumatoid arthritis is one of the most prevalent auto-immune diseases impacting the world's population, causing joint inflammation, synovium growth, and articular cartilage degradation. Transcriptional regulator NF-kB has long been known to play a key role in controlling inflammation in rheumatoid arthritis (RA), but more recent research has shown that NF-kB also plays a principle role in various physiological and pathological aspects such as maturation and activation of T-cell maturation, dysregulated apoptosis and activation of fibroblast cells in synovium as well as hyperactivity of osteoclasts. TNF-α signaling is linked to persistent inflammation and can ultimately lead to pathological consequences such as autoimmune disorders. Insight of the TNF-α signaling mechanism has grown and been used to the treatment of immunological illnesses, resulting in the design of useful therapeutic tools such as TNF-α inhibitors.


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