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Pluripotent stem cells: Trans-differentiation and Signal Modulator Pathways

Supriya Sharma, Nidhi Agarwal

Abstract


Pluripotent stem cells have the ability to differentiate into nearly every cell type in the body. Regenerate tissues or organs lost by traumas, degenerative illnesses, ageing, or cancer have a lot of promise because of this unique potential are called the Cell-based therapies. Induced pluripotent stem cell (IPSC) technology has been discovered as a potential technique for producing patient-specific pluripotent stem cells. However, due of concerns about IPSC reprogramming's selectivity, reliability, pharmacokinetics, and health, it needs to be improved or fundamentally changed before it can be in therapeutic settings. A chemical method to improving and changing the pluripotent stem cells process is seen as a potential option. Hundreds of tiny compounds have been discovered that can substitute reprogram factors and increase pluripotent stem cells reprogramming considerably. Aside from the possibility of creating patient-specific tissues and organs from pluripotent stem cells, trans-differentiation-the direct conversion of one somatic cell type to another-is another promising regenerative medicine method. Recent research has shown a new paradigm of proliferation and differentiation: IPSC transcription factor based trans-differentiation, which involves utilizing transcription factors employed in pluripotent stem cells production to induce trans differentiation.


Keywords


Pluripotent stem cells, Trans-differentiation, Programming, strategies, Somatic cells

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References


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DOI: https://doi.org/10.37628/ijcbcp.v8i2.745

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