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Using of Rat Model Over Other Species: A Review

Nidhi Aggarwal

Abstract


The first domesticated morphological features to be used in studies were rats. Scientists employed the brown rat Rattus norvegicus to study human biology and therapeutics two decades ago, focusing on the consequences of hunger and oxygen deprivation. Rats have been used to answer a wide range of basic science problems relevant to common human ailments in the fields of pharmacology, immunology, physiology, nutrition, behaviour, learning, and toxicity. The article gives an overview just on investigation and addresses the advantages and disadvantages of using rat studies.


Keywords


Models, Rats, Research, Scientists, Disease, Human

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References


Jacob HJ. The rat: a model used in biomedical research. Methods Mol Biol. 2010;597:1–11.

Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, et al. Progress and prospects in rat genetics: a community view. Nat Genet. 2008;40(5):516–22.

Aitman T, Dhillon P, Geurts AM. A RATional choice for translational research? Dis Model Mech. 2016;9(10):1069–72.

James MR, Lindpaintner K. Why map the rat? Trends Genet. 1997;13(5):171–3.

Suckow MA, Hankenson FC, Wilson RP, Foley PL. The laboratory rat. 3rd ed: Elsevier; 2020. p. 1180.

Jacob HJ. Functional genomics and rat models. Genome Res. 1999;9(11):1013–6.

Allen PS, Dell’Italia LJ, Esvelt M, Conte ML, Cadillac JM, Myers DD Jr. Cardiovascular research. In: Suckow MA, Hankenson FC, Wilson RP, Foley PL, editors. The laboratory rat. 3rd ed: Elsevier; 2020. p. 927–5.

Hashway SA, Wilding LA. Translational potential of rats in research. In: Suckow MA, Hankenson FC, Wilson RP, Foley PL, editors. The laboratory rat. 3rd ed: Elsevier; 2020. p. 77–88.

Szpirer C. Cancer research in rat models. Methods Mol Biol. 2010;597:445–58.

Nascimento-Gonçalves E, Faustino-Rocha AI, Seixas F, Ginja M, Colaço B, Ferreira R, et al. Modelling human prostate cancer: rat models. Life Sci. 2018;203:210–24.

Russo J. Significance of rat mammary tumors for human risk assessment. Toxicol Pathol. 2015;43(2):145–70.

Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, van Zwieten MJ. Comparative study of human and rat mammary tumorigenesis. Lab Investig. 1990;62(3):244–78.

Sanders J, Samuelson DJ. Significant overlap between human genome-wide association-study nominated breast cancer risk alleles and rat mammary cancer susceptibility loci. Breast Cancer Res. 2014;16(1):R14.

Ellenbroek B, Youn J. Rodent models in neuroscience research: is it a rat race? Dis Model Mech. 2016;9(10):1079–87.

Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, et al. Rats are the smart choice: rationale for a renewed focus on rats in behavioral genetics. Neuropharmacology. 2014;76 Pt B:250–8.

Carter CS, Richardson A, Huffman DM, Austad S. Bring back the rat! J Gerontol A Biol Sci Med Sci. 2020;75(3):405–15.

Homberg JR, Wohr M, Alenina N. Comeback of the rat in biomedical research. ACS Chem Neurosci. 2017;8(5):900–3.

Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M. Rat genome and model resources. ILAR J. 2017;58(1):42–58.

Mashimo T, Yanagihara K, Tokuda S, Voigt B, Takizawa A, Nakajima R, et al. An ENU-induced mutant archive for gene targeting in rats. Nat Genet. 2008;40(5):514–5.




DOI: https://doi.org/10.37628/ijaba.v8i1.772

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