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“Phage Display” a promising tool for viral diseases

Neha Srivastava


Phage display is a potential technology used in many areas including identification of therapeutic peptides for antiviral purposes. By inserting degenerated oligonucleotides into the phage genes encoding coat proteins, large and diverse peptide libraries can be expressed on the surface of phages. Following incubation of the generated library with a target of interest (viral proteins), selective phages with enriched affinity for such target can be separated and sequenced to determine the identity of the displayed peptides. The identified displayed peptides can be as therapeutic agent against those specific viral diseases. This technology can be used for any microbial diseases however, this review briefly covers the general overview of proteomic phage display and its application in identification of peptide inhibitors against viral diseases.


Phage display, antiviral, peptide inhibitor and viral diseases, Phages

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