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Tendon Injury: Mechanisms and Functions of Transforming Growth Factors-β1

Vikrant Singh

Abstract


Tendon injuries are particularly common, and they can cause a lot of pain, according to medical expenditures, and productivity loss A range of injuries might result in tendonopathy or tendon rupture. Tendinitis or tendinosis can develop in tendons that have been overused or have degenerated intrinsically. The ability of a torn or diseased tendon to mend depends on its anatomic position and the surrounding environment. Tendon injury is a frequent injury that heals slowly and can be treated medically or non-surgically. However, clinical outcomes are not always positive. Tendon repair is aided by growth factors, and many individuals believe that pharmacological intervention might speed up and improve the process. In past years, these have been determined that bio-augmentation procedures offer potential advantages and damages during the tendon healing process. Exogenous TGF-β1 has been shown to speed up tendon repair in numerous studies.


Keywords


Tendon Injury, Functioning, Growth factors, Pharmacological, Mechanism

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References


Majewski M, Widmer KH., & Steinbrück, K. Achilles tendon ruptures: 25 year's experience in sport-orthopedic treatment. Sportverletz Sportschaden. 2002; 16 (4): 167–173.

Nourissat G, Berenbaum F, Duprez D. Tendon injury: From biology to tendon repair. Nat Rev Rheumatol., 2015; 11 (4): 223–233.

Heisterbach PE, Todorov A, Flückiger R, et al. Effect of BMP-12, TGF-β1 and autologous conditioned serum on growth factor expression in achilles tendon healing. Knee Surg Sports Traumatol Arthrosc. 2012; 20 (10): 1907–1914.

Hou Y, Mao Z, Wei X, et al. The roles of TGF-beta1 gene transfer on collagen formation during Achilles tendon healing. Biochem Biophys Res Commun. 2009; 383 (2): 235–239.

Speed, C. Inflammation in tendon disorders. Adv Exp Med Biol. 2016; 920: 209–220.

Docheva D, Müller SA, Majewski M, et al. Biologics for tendon repair. Adv Drug Deliv Rev., 2015; 84: 222–239.

Pakyari M, Farrokhi A, Maharlooei MK et al. Critical role of transforming growth factor beta in different phases of wound healing. Adv Wound Care (New Rochelle). 2013; 2 (5): 215–224.

Zhang AY, Pham H, Ho F, et al. Inhibition of TGF-beta-induced collagen production in rabbit flexor tendons. J Hand Surg Am. 2004; 29 (2): 230–235.

Crispim J, Fernandes HAM, Fu SC, et al. TGF-β1 activation in human hamstring cells through growth factor binding peptides on polycaprolactone surfaces. Acta Biomater. 2017; 53: 165–178.

Behzad H, Sharma A, Mousavizadeh R, et al. Mast cells exert pro-inflammatory effects of relevance to the pathophyisology of tendinopathy. Arthritis Res Ther. 2013; 15 (6): 184.

Ciardulli MC, Marino L, Lamparelli EP, et al. Dose-response tendon-specific markers induction by growth differentiation factor-5 in human bone marrow and umbilical cord mesenchymal stem cells. Int J Mol Sci. 2020; 21 (16): 5905.

Beredjiklian PK, Favata M, Cartmell JS. Et al. Regenerative vs. reparative healing in tendon: A study of biomechanical and histological properties in fetal sheep. Ann Biomed Eng. 2003; 31 (10): 1143–1152.

Wang Y, He G, Tang H, et al. Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway. Cell Prolif. 2019; 52 (4): e12650.

Alim MA, Peterson M, Pejler G. Do mast cells have a role in tendon healing and inflammation? Cells. 2020; 9 (5): 1134.

Vinhas A, Rodrigues MT, Gomes ME. Exploring stem cells and inflammation in tendon repair and regeneration. Adv Exp Med Biol. 2018; 1089: 37–46.




DOI: https://doi.org/10.37628/ijmb.v8i1.760

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