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Production of Therapeutic Proteins: A Review

Amandeep Kushan

Abstract


Therapeutic proteins will be proteins that are engineered in the lab for pharmaceutical utilize. Insulin was the main remedial protein to be acquainted with treat diabetes in the 1920s. Because of recombinant DNA-technology proteins can be produced in particular host cells (e. g. bacteria, yeast or mammalian cells) under characterized conditions. Contingent upon the necessities of the protein the production host must be picked precisely. Mammalian cells are the primary host of decision in light of the fact that their posttranslational changes, for example, glycosylation and sialylation has the greatest effect on the protein's pharmacokinetics and effectiveness.

Protein-based treatments are utilized for instance as a part of the treatment of:
• Cancer
• Infectious diseases
• Hemophilia
• Anemia
• Multiple sclerosis
• Hepatitis B/C

Therapeutic proteins allow an individualized treatment approach by supporting a particularly focused on Therapeutic process by remunerating the lack of an essential protein.

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References


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DOI: https://doi.org/10.37628/ijmb.v1i2.128

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