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Computational Analysis of TNRC9 (TOX3) Gene Related to Breast Cancer

K. S. Ravi Teja, R Kowshik Aravilli, Jahnavi R, Sai Lakshmi G, Harshavardhani V, Alpana Joshi


Breast cancer is a disease in which women are more prone than men. Breast cancer completely depends upon type of cells that are present and cells that turn normal cells to abnormal cells. Breast cancer starts in the breast or the breast cancer which can be caused by some other cancers that had present in the body. In the United States, these cancers will affect more than 40,000 women. Women are typically the ones who develop these types of cancer. This means that the cancer will disrupt other cells and spread throughout the body, among those cells. Among those genes TNRC9 (trinucleotide-repeat-containing 9) also called as TOX3 is a gene which can induce breast cancer. This gene is involved in cell proliferation, and migration. Our aim of the study is to the gene (TOX3) which can downregulate the BRCA1 gene and proliferate breast cancer. TOX3 gene contains SNPs that are connected to breast cancer. TOX3 expression is highly significant in luminal subtype cancers. So n the current study we have focused on the Gene interaction, protein linkage studies, protein structure, peptide Analysis using different algorithms etc. among all we identified that TOX3 is more expressive than BRCA1 gene. Few Insilico studies revealed that ovarian and breast cancer cells of TOX3 and BRCA1 genes are inversely correlated.

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