A Brief of Biochemistry: Nucleic Acids
Abstract
DNA and RNA are nucleic acids that encode genetic information and are processed by cells to produce RNA and proteins, which are required for living creatures to perform. Such content may be duplicated and handed on to another generation thanks to a very well arrangement of a DNA double helix structure. This section discusses the structure and composition of nucleic acids. Several of the researchers were honored with Excellence Award for their achievements in study, and the article gives background information and focuses on the following of initial research that contributed to the knowledge of such an important molecule and how it functions. The DNA structure, how everything is organized in chromosome, or how it's copied before cellular division. If the genetic concept has evolved because of how DNA is duplicated into RNA, transcription, and translated into protein, translation, since conception.
Keywords
Full Text:
PDFReferences
Blackburn EH. Telomeres and Telomerase: The Means to the End (Nobel Lecture) 49, Int. Ed.
Angewandte Chemie. 2010; 7405–7421.
Ehrenberg M. (2009) Scientific Background on the Nobel Prize in Chemistry 2009 Structure and
Function of the Ribosome, The Royal Swedish Academy of Sciences,
Kornberg R.D. (2007) The Molecular Basis of Eukaryotic Transcription (Nobel Lecture) 32, Int.
Ed. Angewandte Chemie. pp. 12955–12961.
Dahm R. (2008) Discovering DNA: Friedrich Miescher and the early years of nucleic acid
research. Hum. Genet. 122, 565–581 10.1007/s00439-007-0433-0
McCarty M. (2003) Discovering genes are made of DNA. Nature 421,
Maddox B. (2003) The double helix and the “wronged heroine”. Nature 421, 407–408
Kemp M. (2003) The Mona Lisa of modern science. Nature 421, 416–420 10.1038/nature01403
Franklin R.E. and Gosling R.G. (1953) Molecular configuration in sodium thymonucleate. Nature
, 740–741
Meselson M. and Stahl F.W. (1958) The replication of DNA in Escherichia coli. Proc. Natl. Acad.
Sci. U.S.A. 44, 671–682
Watson J. and Crick F. (1953) Molecular structure of nucleic acid. A structure for deoxyribose
nucleic acid. Nature 171, 737–738
Goodsell D. (2010) Molecule of the month: ribosome.
Myasnikov A.G. (2014) The molecular structure of the left-handed supra-molecular helix of
eukaryotic polyribosomes. Nat. Commun. 5, 5294.
Afonin, K.A., Bindewald, E., Yaghoubian, A.J., Voss, N., Jacovetty, E., Shapiro, B.A., et al.
(2010). In Vitro assembly of Cubic RNA-Based Scaffolds Designed In Silico. Nat. Nanotech 5,
–682.
Alon, D.M., Voigt, C.A., and Elbaz, J. (2020). Engineering a DNAzyme-Based Operon System
for the Production of DNA Nanoscaffolds in Living Bacteria. ACS Synth. Biol. 9, 236–240.
Burmeister, P.E., Lewis, S.D., Silva, R.F., Preiss, J.R., Horwitz, L.R., Pendergrast, P. S., et al.
(2005). Direct In Vitro Selection of a 2′-O-Methyl Aptamer to VEGF. Chem. Biol. 12, 25–33.
Chandler, M., Panigaj, M., Rolband, L.A., and Afonin, K.A. (2020). Challenges in Optimizing
RNA Nanostructures for Large-Scale Production and Controlled Therapeutic Properties.
Nanomedicine 15 (13), 1331–1340.
Chen, Q., Yu, S., Myung, N., and Chen, W. (2017). DNA-Guided Assembly of a Five-Component
Enzyme cascade for Enhanced Conversion of Cellulose to Gluconic Acid and H2O2. J.
Biotechnol. 263, 30–35.
Cruz-Acuña, M., Halman, J.R., Afonin, K.A., Dobson, J., and Rinaldi, C. (2018). Magnetic
Nanoparticles Loaded with Functional RNA Nanoparticles. Nanoscale 10 (37), 17761–17770.
Delebecque, C.J., Lindner, A.B., Silver, P.A., and Aldaye, F.A. (2011). Organization of
Intracellular Reactions with Rationally Designed RNA Assemblies. Science 333, 470–474.
Donovan, J., Whitney, G., Rath, S., and Korennykh, A. (2015). Structural Mechanism of Sensing
Long dsRNA via a Noncatalytic Domain in Human Oligoadenylate Synthetase 3. Proc. Natl.
Acad. Sci. U.S.A. 112, 3949–3954.
DOI: https://doi.org/10.37628/ijbb.v8i1.775
Refbacks
- There are currently no refbacks.