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COMMUNICATION BETWEEN GUT MICROBES AND BRAIN

Rishabh Kansal

Abstract


Clinical and preclinical studies have shown that there is bidirectional interaction between brain and gut microbiome. Gut microbes communicate to CNS through at least 3 channels, which involves nervous, endocrine, and immune signaling mechanisms. Gut bacteria also influence the development of CNS and stress responses. Gut bacteria can also provide protection from central effects of infection and inflammation as well as modulate normal behavioral responses. The vagus nerve has also emerged as an important means of communicating signals from gut microbes to CNS. A systems biological model is proposed that posits circular communication between brain, gut and gut microbes and in which disturbance at any level can dysregulate whole circuit.


Keywords


Gut microbes, brain, vagus, microbiota, behavior, stress, CNS–Central Nervous System, BDNF–Brain Derived Neurotrophic Factor ENS–Enteric Nervous System

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References


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DOI: https://doi.org/10.37628/ijbb.v7i2.681

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