Study of  hs-CRP,  Blood Glucose and Blood Pressure to evaluate the risk of Nephropathy in type 2 Diabetes

Jay Prakash Sah; Chandrakant Yadav; Dipendra Kumar Yadav; Sapana Subedi; Sujana Neupane; Sangita Pandey

doi:10.37628/ijbb.v1i1-2.6

Study of hs-CRP, Blood Glucose and Blood Pressure to evaluate the risk of Nephropathy in type 2 Diabetes

Jay Prakash Sah, Chandrakant Yadav, Dipendra Kumar Yadav, Sapana Subedi, Sujana Neupane, Sangita Pandey

Abstract

Diabetes nephropathy is an emerging serious health problem for diabetic patients. Many studies have demonstrated that high-sensitive C-reactive protein (hs-CRP is a marker of inflammation. It may play a significant role as predictor of inflammation in nephropathy patients when it could test with other reliable marker. The aim of present study was to estimate the association among hs-CRP levels, fasting blood glucose and blood pressure level. A quantitative, analytical, hospital-based study was done by enrolling 89 type-2 diabetic patients conducted at Tertiary Care Hospital. The authors analyzed serum concentrations of hs-CRP, fasting blood glucose and blood pressure of type-2 diabetic patients. In this study, the authors found the significant association between serum hs-CRP and fasting blood glucose level (P values = 0.001). Furthermore, serum hs-CRP was not correlated with blood pressure (P > 0.161). In the same way, fasting blood glucose was not also significantly correlated with blood pressure of diabetic patients. This study concludes that serum hs-CRP value in type-2 diabetic patients is significantly correlated with fasting blood sugar level. And there is no correlation of both serum hs-CRP and fasting blood glucose level with the risk factors especially blood pressure of type-2 diabetes. The significance of these findings emphasizes to choose these associations for early screening and staging of diabetic nephropathy.

Keywords

Blood Pressure, Diabetic Nephropathy, Fasting blood Glucose, High sensitivity-C reactive protein

Full Text:

PDF

References

Kasper DI, Fauci AS, Hauser SL, Longo DL, Jameson JL. Harrison's Principles of Internal Medicine 3. 2005;16(3).

Agarwal N, Sengar NS, Jain PK, Khare R. Nephropathy in Newly Diagnosed Type 2 Diabetics with Special Stress on the Role of Hypertension. Association of Physian India. 2011;59:145-47.

Nepal Diabetes association (NDA). Annual report. 2013.

American Diabetes Association. Nephropathy in diabetes (Position Statement) Diabetes Care. 2004;27(1):79-83.

Crook M. Type 2 diabetes mellitus: a disease of the innate immune system? An update. Diabet Med. 2004(21):203-7.

Dalla VM, Mussap M, Gallina P. Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes. J Am Soc Nephrol. 2005(16):78-82.

Martha RM , Fernando GR. Increased levels of CRP in Non-controlled Type II diabetic subjects. Journal of Diabetes and its complications. 1999(13): 211-215.

Blake GJ. C-reactive protein and other inflammatory risk markers in acute coronary syndromes. Journal of the American College of Cardiology. 2003;41(4):37-42.

Wang CH, Weisel RD, Fedak PW, Dumont AS, Szmitko P, Li RK, Mickle DA, Verma S. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth musles. Circulation. 2003(107):1783-90.

Pasceri V WJYE. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 2000(102):2165-8.

Venugopal SK, Yuhanna I, Shaul P. Demonstration that C reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation. 2002(106):1439-41.

M B. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-20.

M C. Pathogenesis, prevention and treatment of diabetic nephropathy. Lancet. 1998.

Pepys MB. C-reactive protein: a critical update. J Clin Invest. 2003;111(12):1805-12.

Bhattarai MD SD. Learning the lessons – preventing type 2 diabetes in Nepal. Diabetes voice. 2007;52(2):9-10.

Choudhury TA LS. Complications and cardiovascular risk factors in South Asians and Europeans with early-onset type 2 diabetes. QJM. 2002;95:241-6.

Urooj Taheed Baluch IGK, Niazi R, Nighat B, Tahir F. C- Reactive Protein As A Low Grade Inflammatory Marker in type 2 diabetic nephropathy. Ann Pak Inst Med Sci. 2011;7(4):217-21.

Liu F CH, Huang XR, Chung AC, Zhou L, Fu P. C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes. Diabetologia. 2011;54:2713-23.

Sugam S, Shrestha R, Poudel B, Sigdel M. Serum Urea and Creatinine in Diabetic and non-diabetic Subjects. Journal of Nepal Association for Medical Laboratory Sciences. 2008;9(1):11-2.

Mittal A SB, Kumar A, Chandrasekharan N, Sunka A. Diabetes mellitus as a Potential Risk Factor for Renal Disease among Nepalese. Nepal journal of Epidemiology. 2010;1(1):22-5.

Jiji Inassi VR. role of duration of diabetes in the development of nephropathy in type 2 diabetic patients. National Journal of Medical Research. 2013;3(1):1-8.

Chen-Chung F Y-ML, Jer-Chuan Li1, Du-An Wu. Association of C- reactive Protein and Traditional Risk Factors with Nephropathy in the Elderly Patients with Diabetes. Taiwan Geriatrics & Gerontology.3:202-10.

Khalaf SJ. Study of some biochemical markers in diabetic patients. Tikrit Medical Journal. 2010;16(2):84-7.

Sun H, Koike T, Ichikawa T. C-reactive protein in atherosclerotic lesions: its origin and patho-physiological significance. American Journal of Pathology. 2005; 167(4): 1139–48.

Sacks DB, Bruns DE, Goldstein DE, Maclaren NK. Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. Clin Chem. 2002;48(3):436-72.

Azza ME, Tarek MA, Rizk AE, Wafaa AM. Role of hypertension and metabolic abnormalities in the development of diabetic nephropathy among Egyptian patients with type 2 diabetes. Nature and Science 2011; 9(7):220-8.

Kaefer M, Piva SJ, De-Carvalho JA, Da- Silva DB, Becker AM, Coelho AC, Durate MM, Moresco MN. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. clin biochem. 2009.

Mojahedi MJ, Bonakdaran S, Hami M, Sheikhian MR, Shakeri MT, Aiatollahi H. Elevated Serum C-Reactive Protein Level and Microalbuminuria in Patients With Type 2 Diabetes Mellitus. Iranian Journal of Kidney Diseases .2009;3:12-6.

LING Yan, LI Xiao-mu and GAO Xin. Cross-sectional association of serum C-reactive protein and uric acid with albuminuria in Chinese type 2 diabetic patients. Chinese Medical Journal. 2013;126 (21):4023-29.

Kanga ES, Kimb JH, Ahna CW, Parkc CW, Chaa BS, Lima SK, Kima KR, Leea HC. Relationship of serum high sensitivity C-reactive protein to metabolic syndrome and microvascular complications in type 2 diabetes. Diabetes Research and Clinical Practice. 2005:151–59.

Mohan K, Sultana M.Studies on serum lipids, lipoproteins and high sensitive C-Reactive protein in type 2 diabetes. Indian Journal of Science and Technology. 2011;4(3):185-91.

DOI: https://doi.org/10.37628/ijbb.v1i1-2.6

Refbacks

There are currently no refbacks.