Emulsomes-based Formulations for Effective Delivery of Small Molecules: Recent Advances and Modern Applications Perspectives

Abstract

Oral administration is the simplest, most cost-effective, and most important form of medication delivery. As a result, scientists have faced difficulty in improving dosage formulations, particularly for the goal of extended-release. Vesicular drug delivery methods were created to address issues with medicines such as low bioavailability, protection from the hostile stomach environment, and protection against degrading gastric enzymes. Emulsomes were created as a new lipoidal vesicular system with an internal solid fat core covered by a phospholipid bilayer, bypassing many of the drawbacks associated with previous systems. This technique is intended to serve as a carrier for medicines that are poorly soluble. The medication is encased in emulsomes, which allows it to stay in the systemic circulation for longer. Furthermore, emulsomal-based formulations of genetic medicines with obvious systemic usefulness, such as antisense oligonucleotides and plasmids for gene therapy, are becoming more widely accessible. This review discusses the concept of emulsomal drug delivery, summarizes the success of emulsomes for the delivery of small molecules, and pays special attention to the formulation design, advantages, biopharmaceutical aspects, stability aspects, and other aspects of drug delivery, including future aspects.