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Synergistic Association of CHRNA5 Polymorphism towards Increased Susceptibility to Squamous Cell Lung Cancer

Yashila Girdhar, Ankita Pandey, Sugandha Asthana, Kush Chopra




Aim: Recent studies have been done on European, African Americans, Japanese, Bangladeshis and Koreans to find out the relationship between genetic variants of CHRNA5 (rs16969968) polymorphism and risk of lung cancer. The results have been seen contradictive in different ethnic population. But not a single study has been reported on North Indian population for CHRNA5 (rs16969968) polymorphic gene towards lung cancer risk. The present case-control study performed analysis of genetic variation CHRNA5 (rs16969968) gene using 50/50 study subjects in association with lung cancer risk with smoking status. Methods: The case-control study was evaluated for the CHRNA5 polymorphism by using a PCR-RFLP method. Results: There has been no significant association have been found in relationship between CHRNA5 polymorphic gene and risk of lung cancer (OR= 0.22; 95%CI=0.27-1.7; p= 0.80). However, the study has also evaluated the genetic variants in CHRNA5 polymorphism with respect to different histology of lung cancer but no significant OR has been found in this relation to increase risk of lung cancer (OR=0.23; 95%CI= 0.2-1.6; p=0.40). Further, study subjects stratified according to smoking status and pack year but similarly it has been seen that in North Indian population smoking has not significant effects on the D398N polymorphism in α5 subunit of nAChRs coded by CHRNA5 gene having G>A mutation in population (OR= 0.46; 95%CI= 0.6-1.3; p= 0.97). Conclusion: The polymorphism in the CHRNA5 gene seem to be important risk modifiers for lung cancer and related histological subtypes, along with smoking population.

Keywords: lung cancer, nicotine, CHRNA5, smokers, North India

Cite this Article: Ankita Pandey, Yashila Girdhar, Sugandha Asthana, Kush Chopra. Synergistic association of CHRNA5 polymorphism towards increased susceptibility to Squamous Cell Lung Cancer. International Journal of Genetic Engineering and Recombination. 2019; 5(2): 20–29p.

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