Cellular Senescence and Its Role in Cancer
Abstract
as cell senescence. Understanding the causes and outcomes of cell senescence has given novel bits of knowledge into how cells respond to stress, particularly genotoxic stress, and how this cell reaction can influence complex organismal procedures, for example, the occurrence of cancer and ageing.
Keywords
Full Text:
PDFReferences
Campisi J. Aging, cellular senescence, and cancer, Ann Rev Physiol. 2013; 75: 685–705p.
Hanahan D., Weinberg R.A. The hallmarks of cancer, Cell. 2000;
(1): 57–70p.
Rodier F., Campisi J. Four faces of cellular senescence, J Cell Biol. 2011; 192(4): 547–56p.
Xu M., Palmer A.K., Ding H., et al. Targeting senescent cells enhances
adipogenesis and metabolic function in old age, eLife. 2015; 4.
Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell
strains, Exp Cell Res. 1961; 25: 585– 621p.
Gavrilov L.A., Gavrilova N.S. The reliability theory of aging and
longevity, J Theor Biol. 2001; 213(4):527–45p.
Bowen R.L., Atwood C.S. The reproductive-cell cycle theory of
aging: an update, Exp Gerontol. 2011; 46(2): 100–7p.
Williams G.C. Pleiotropy, natural selection, and the evolution of
senescence, Evolution. 1957; 11: 398–411p.
Fabian D., Flatt T. The evolution of aging, Scitable. 2014.
Bernstein H., Payne C.M., Bernstein C., et al. Cancer and aging as
consequences of un-repaired DNA damage, In: New Research on DNA
Damage. Kimura H., Suzuki A., Nova Science Publishers; 1–47p. ISBN 978-1604565812.
Ames B.N., Gold L.S. Endogenous mutagens and the causes of aging and cancer, Mutat Res. 1991; 250(1-2): 3–16p.
Burton D.G., Faragher. Cellular senescence: from growth arrest to
immunogenic conversion R.G., Age.2015; 37.
Sager R. Senescence as a mode of tumor suppression, Environ Health Persp. 1991; 93: 59–62p.
Allsopp R.C., Chang E., Kashefi- Aazam M., et al. Telomere shortening is associated with cell division in vitro and in vivo, Exp Cell Res. 1995; 220:194–220p.
Wright W.E., Shay J.W. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology, Nat Med. 2000; 6: 849–51p.
DOI: https://doi.org/10.37628/ijcbcp.v2i1.68
Refbacks
- There are currently no refbacks.