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Heterocyclic- Derivatives with Aspirin Drug (Synthesis, Characterization, Studying of Its Effect on Cancer Cells)
Abstract
Aspirin is considered one of the very important compounds in the treatment of clotting, blood clots and other diseases, and due to its importance, aspirin has been linked with heterocyclic compounds to increase its importance and we chose thiosemicarbazide to form cyclic compounds such as triazole and thiazole and other heterocyclics that contain more than two heterocyclic compounds within the same ring, including sulfur. And nitrogen. This work involved preparation of new important pharmacological Derivatives from Aspirin drug via cyclization of thiosemicarbazide with carbonyl group of esters by using special conditions sulfuric in steps of reactions to yield Aspirin-thiadiazole, Aspirin-Triazole and other derivatives. All reactions are followed by TLC -chromatographic and all the synthesized compounds have been identified by using various chemical techniques, like (1H.NMR-spectra , 13C.NMR-spectra , FT. IR- spectra), melting points, physical properties and studying of its effect on breast cancer cells .
Keywords: Aspirin drug, heterocyclic, anticancer studying, breast cancer, thiadiazole, triazole, thiosemicarbazide, azo
Cite this Article: Asmaa Kefah Mahdi, Nagham Mahmood Aljamali. Heterocyclic- Derivatives with Aspirin Drug (Synthesis, Characterization, Studying of Its Effect on Cancer Cells). International Journal of Cell Biology and Cellular Processes. 2020; 6(2): 1–20p.
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