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Salivary IgA Levels in Patients with Oral Sub mucous Fibrosis: A Study

Shoborose Tantray, Nazima Nasrullah, Sajad ul Islam Mir, Seema Sharma


Salivary IgA has an important role in defense in the oral cavity. It originates from the secretory epithelial cells and also from the vascular compartment. Oral submucous fibrosis (OSMF) is a debilitating, potentially premalignant disorder. Although areca nut is the principle causative agent, it has been reported that this disease is immunologically mediated. Betel quid chewing has a great effect on the immunoglobulin profile in saliva; hence we studied the salivary IgA levels in these patients. To assess the salivary IgA levels in OSMF patients. Study comprised three groups. Group I 20 clinically diagnosed OSMF cases and Group II 40 smokeless tobacco chewers and Group III 20 controls.  In smokeless tobacco chewer’s salivary IgA levels was decreased when compared with controls and in OSMF patients it was increased compared to control group. The saliva of smokeless tobacco chewers contain altered IgA levels which apparently initiate an immunological incompetence and it could promote effect of cotinine on oral mucosa and result in fibrosis.


Salivary IgA, Betal quid, Oral submucous fibrosis (OSMF), HLA (human leukocyte Antigen), Nicotine, Serum immunoglobulin

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