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A Localized Warburg Effect and Prostatic Cancer: A Biochemical Approach

Vásquez E. F., Chimoy P. J.

Abstract


ABSTRACT
Prostatic cancer is the third most frequent type of cancer among all cancers and the second most diagnosed and death-related among men, 28 men per 100 000 are affected by this disease varying according to the level of development of the country. Prostatic-fluid-secreting luminal cells normally accumulate zinc up to 200 times the amount found in plasma, Zinc blocks m-aconitase physiologically decreasing respiratory chain (OXPHOS) energy production which increases glycolytic energy source, a physiologic Warburg-like effect no found in other tissues. A Localized Warburg effect was surveyed as a causative of prostatic cancer onset and progression. Sexual behavior accompanied with Luminal cells exhaustion which decreases zinc levels render a local inflammation which along with systemic xenobiotics and pro-inflammatory molecules signals in the basal layer of the prostatic secretory glands render an inflammatory micro-environment which precludes malignancy. Furthermore, Loss of lower abdomen, pelvic floor muscles and penile ligaments strength generate an irregular oxygen supply, initially OXPHOS cells undergo Warburg metabolism this onset is not detected in Positron Emission Tomography-Computed Tomography, then OXPHOS cells signal cancer associated fibroblasts (CAFs) which undergo the so-called Reverse Warburg effect, finally adipocytes also signal OXPHOS cells to undergo Warburg metabolism in the metastatic stage of prostatic cancer progression. Prophylactic measures are suggested: Modification in sexual behavior, regain lower abdomen bio-mechanics, Kegels for men, penile ligaments routine of exercises, the maintenance of a referenced body weight and regular aerobic exercises.
Keywords: inflammation, localized, luminal cells, prostatic cancer, Warburg effect

Cite this Article: Vásquez E.F., Chimoy P.J. A Localized Warburg Effect and Prostatic Cancer: A Biochemical Approach. International Journal of Cell Biology and Cellular Processes. 2019; 5(2): 13–29p.


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DOI: https://doi.org/10.37628/ijcbcp.v5i2.498

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