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Structure of an Anti-CRISPR Protein

Anuradha Chaudhary

Abstract


Bacterial CRISPR–Cas adaptive immune systems utilize small guide RNAs to protect against phage infection and invasion by outside genetic components. We heretofore showed that a get-together of Pseudomonas aeruginosa phages encode against CRISPR proteins that inactivate the type I-F and I-E CRISPR–Cas frameworks using particular mechanisms. Here, we present the three-dimensional structure of a hostile to CRISPR protein and guide a valuable surface that is essential for its powerful inhibitory action. The connection of the counter CRISPR protein with the CRISPR–Cas complex through this utilitarian surface is proposed to keep the binding of target DNA.

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References


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DOI: https://doi.org/10.37628/ijcbcp.v2i2.142

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