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Virosomes: Understanding the Modern Concepts and Latest Applications

Mamta Kadawla

Abstract


A virosome is a cutting-edge hybrid drug delivery method that combines the benefits of viral and non-viral vectors. A virosome has been shown to transport a variety of physiologically active substances, including nucleic acids, peptides, proteins, and tiny chemical compounds, according to research. Surface changes of virosomes may be used to enable targeted medication delivery utilising virosome-based devices. There are presently a variety of virosome-based preventive and therapeutic medicines on the market with excellent safety profiles. For virosome-based drug delivery systems, cancer therapy is a major battleground. The basic idea, production methods, functioning mechanisms, preclinical investigations, and clinical uses of virosomes are all included in this study.

 


Keywords


Virosomes, Drug Delivery, Vaccine, Mechanisms, Preparations, Applications

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References


Daemen T, de Mare A, Bungener L, de Jonge J, Huckriede A, Wilschut J. Virosomes for antigen and DNA delivery. Adv Drug Deliv Rev. 2005;57(3):451-63.

Kaneda Y. Virosomes: evolution of the liposome as a targeted drug delivery system. Adv Drug Deliv Rev. 2000;43(2-3):197-205.

Kalra N, Dhanya V, Saini V, Jeyabalan G. Virosomes: as a drug delivery carrier. Am J Adv Drug Deliv. 2013;1(1):29-35.

Singh N, Gautam SP, Kumari N, Kaur R, Kaur M. Virosomes as novel drug delivery system: an overview. PharmaTutor. 2017;5(9):47-55.

Shaikh SN, Raza S, Ansari MA, Khan GJ, Athar SH. Overview on virosomes as a novel carrier for drug delivery. J Drug Deliv Ther. 2018;8(6-s):429-34.

Metcalfe IC, Glück R. Virosomes for vaccine delivery. In: Schijns VEJC, O'Hagan DT, editors. Immunopotentiators in Modern Vaccines. Academic Press; Burlington: 2006; 179-89.

Rathor S, Soni P, Lal D. Unique Drug Delivery System: Virosomes. Res J Pharm Dosage Form Technol. 2019;11(4):304-8.

Bungener L, Huckriede A, Wilschut J, Daemen T. Virosomes as a vaccine delivery system. In: 14th European Immunology Meeting (EFIS 2000). Medimond Publishing Company. 2000:845-50.

Nalawade R, Nalawade A, Patwa H, Ghode S, Raut R, Chatur VM. Virosomes: A Drug Carrier System. J Hosp Pharm. 2021;16(1):1-9.

Gaurav B, Manisha K, Vilasrao K. Virosome–drug and vaccine delivery system. World J Pharm Pharm Sci. 2014;3(10):437-47.

Cusi MG. Applications of influenza virosomes as a delivery system. Human Vaccine. 2006;2(1):1-7.

Hodgson CP, Solaiman F. Virosomes: cationic liposomes enhance retroviral transduction. Nature Biotechnol. 1996;14(3):339-42.

Adamina M, Guller U, Bracci L, Heberer M, Spagnoli GC, Schumacher R. Clinical applications of virosomes in cancer immunotherapy. Exp Opin Biol Ther. 2006;6(11):1113-21.

Bron R, Ortiz A, Dijkstra J, Stegmann T, Wilschut J. Preparation, properties, and applications of reconstituted influenza virus envelopes (virosomes). Method Enzymol. 1993;220:313-31.

Wilschut J. Influenza vaccines: the virosome concept. Immunol Lett. 2009;122(2):118-21.

Kalra A, Sharma S. Virosomes: A Viral Envelope System Having a Promising Application in Vaccination and Drug Delivery System. Nanopharm Adv Deliv Syst. 2021:145-60.

Patel SS, Patel MJ, Patel NM. Need, Development and application of Virosomal system in medicine. Int J Pharm Sci Nanotechnol. 2010;3(3):1065-74.

Kaneda Y. Virosome: a novel vector to enable multi-modal strategies for cancer therapy. Adv Drug Deliv Rev. 2012;64(8):730-8.

Amacker M, Moese S, Kammer AR, Helenius A, Zurbriggen R. Influenza Virosomes as Delivery Systems for Antigens. In: Lene J, Hanne MN, editors. Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. John Wiley & Sons; Philadelphia: 2009;377-97.

Asadi K, Gholami A. Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review. Int J Biol Macromol. 2021;182:648-58.


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