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A Preliminary Study of the Regenerative Effect of Overo Flower (Cordia lutea Lam.) Infusion in the Liver of Rats Consuming Alcohol Chronically

Edwin Fernando Vásquez Vásquez, Pedro Jorge Chimoy Effio

Abstract


Alcohol consumption causes the Alcoholic Liver Disease which includes a series of pathologies starting with a Fatty Infiltration, later Hepatic Inflammation, Fibrosis, Cirrhosis, and eventual Hepatocellular Carcinoma. The prevalence of these changes generates expenses in the health system and discomfort for the patient. Moreover, the current standard Corticosteroid treatment is not effective in all patients, 30-40% dies six months after initial diagnosis and new therapies including Plant metabolites are investigated to better the prognosis of patients. It was studied the hepatic regeneration of Rats which consumed alcohol chronically treated with Overo Flower (Cordia lutea Lam.) infusion. Rats (Rattus norvegicus, strain Sprague-Dawley) (n=18), weighting 192.6 +- 26.74g were divided in three groups (n=06) and treated for 120 days: Group I, consumed water ad libitum; Group II, consumed alcohol 4% v/v ad libitum; Group III, consumed alcohol 4% v/v and then 21 days of Overo Flower infusion also ad libitum. GOT and GPT Transaminases levels were measured at days: 0, 45, 90, 120 and 141. Livers were perfused, fixed, and cuts were Eosine-Hematoxylin stained. GOT and GPT enzymes were not different at every measurement between groups. The average alcohol consumption of groups II and III was statistically similar (p > 0. 05), global mean = 3.14 +- 0.44 g/day. The hepatic fatty degeneration was statistically higher (p < 0.05) in group II (10.5%) than in groups I (1.3%) and III (2.5%) where it was similar (p > 0.05). Furthermore, in group II white blood cells were observed. The average Overo Flower consumption was 222.14 +- 20.4 mg/kg/day. The consumption of Overo Flower infusion regenerated the fatty liver of rats which consumed alcohol chronically.

 

Keywords: Overo Flower, Cordia lutea Lam., Alcohol Consumption, Liver Regeneration, Rattus norvegicus

Cite this Article: Edwin Fernando Vásquez Vásquez, Pedro Jorge Chimoy Effio. A Preliminary Study of the Regenerative Effect of Overo Flower (Cordia lutea Lam.) Infusion in the Liver of Rats Consuming Alcohol Chronically. International Journal of Animal Biotechnology and Applications. 2020; 6(2): 1–8p.


Keywords


Overo Flower, Cordia lutea Lam., Alcohol Consumption, Liver Regeneration, Rattus norvegicus

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DOI: https://doi.org/10.37628/ijaba.v6i2.609

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