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Nitric Oxide & Inducible Nitric Oxide Synthase: A Glimpse on Biological Role

Dr. Promila Sharma, Ashish Thapliyal

Abstract


Nitric oxide (NO) is a multifunctional molecule having numerous physiological and pathophysiological functions. It is synthesized from L-arginine by three different isoforms of nitric oxide synthase (NOS), which are categorized into two subtypes; constitutive nitric oxide synthase (cNOS) and inducible nitric oxide synthase (iNOS). Constitutive nitric oxide synthase (cNOS) is constitutively expressed in the cells, while inducible nitric oxide synthase (iNOS) is expressed within several hours after the stimulation of cells only by inflammatory signals such as cytokines or endotoxins. It is important to understand the regulation of NO as NO produced by iNOS is beneficial when produced in controlled manner but uncontrolled over-production of NO can be detrimental also.

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References


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DOI: https://doi.org/10.37628/ijpb.v1i1-2.16

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