Role of Iron in Gall Stone Formation

Abstract

incidence of gallstone disease is increasing considerably. In developed countries, at least 20% of women over the age of 40 suffer from gallstones. Till now various etiological factors have been described to be in definite association with cholelithiasis. So while searching for other parameters, Iron deficiency was found to be a new parameter of interest in the etiology of gallstone. Aim and objective of the study was to co-relate the iron deficiency anaemia with gallstone disease. 140 patients of cholelithiasis and cholelithiasis with choledocholithiasis confirmed by ultrasonography were divided into two groups, Group-A (non-anaemic) and Group-B (anaemic) based on haemoglobin level. Serum cholesterol, gall bladder bile cholesterol of both the groups were studied and compared. Total serum cholesterol was not different in the two groups (p>0.05). Gall bladder bile cholesterol was significantly higher in anaemic (386.69+81.72) than in non-anaemic patients (224.49+37.87). The difference was found statistically significant (p>0.001). We concluded that low serum iron levels lead to bile supersaturation with respect to cholesterol which leads to gallstone formation.

Keywords: iron deficiency, gallstone, NOS, bile, cholelithiasis, ENZOPAK

Cite this Article: Firdous Ahmad Najar, Iqbal Aziz, Anis Ismail, Masarat Fatima. Role of Iron in Gall Stone Formation. International Journal of Molecular Biotechnology. 2019; 5(2): 24–29p