Parkinson’s Disease: A Brief Outlook

Abstract

The neurodegenerative disorders are referred to the group of chronic as well as progressive degenerative disorders that are characterized by the gradual loss of neurons of the CNS, mainly the brain.¹It involves degeneration of a circumscribed group of neurons that may be functionally or neuroanatomically connected.² There cause deterioration of neuron tissues during the process or progression of neurodegenerative disorders. Neurons that get degenerated cannot be replaced which may lead to dementia, cognitive loss, Parkinson’s disease, Amyotrophic lateral sclerosis, Alzheimer’s disease and degeneration of the cerebellum. Thus any pathological process which results in the neuronal death have irreversible consequences.³ Prevalence of it increases with age and affects 1% of the population above 60 years. The onset of the disease is usually at an age of 65 to 70 years. The onset of this disease before 40 years was reported in less than 5% from the cohort based population studies.

Keywords: apoptosis, central nervous system, MAO-B, dopaminergic blockers, α-synuclein, SNpc

Cite this Article: Uday Raj Sharma, Anjali S., Surendra V., Nageena Taj. Manjunatha PM. Parkinson’s Disease: A Brief Outlook. International Journal of Molecular Biotechnology. 2019; 5(2): 11–23p.