Alcohol Consumption, Organ Damage and Overo Flower (Cordia lutea Lam.): A Biochemical Approach

Abstract

2.4 billion people drink alcohol, as a result around 3 million people die each year due to alcohol-related pathlogy since their consumption is considered a cause component that derives from their interaction between the Xenobiotic per se and products of its oxidative metabolism and non-oxidative. Organ damaged casused by alcohol consumption was reviewed from a Biochemical perspective and the use of Overo Flower for the treatment of such injuries. The oxidative metabolic pathway is carried out by the enzymes alcohol dehydrogenase (ADH) which catalizes Ethanol Acetaldehyde producing NADH in the cytosol, and Acetaldehyde Acetate by the enzyme Acetaldehyde Dehydrogenase (ALDH) in the cytosol and mitochondria producing NADH; while the non-oxidative metabolism produces ethyl-esters fatty acids, phosphatidyl etanol and etanol-protein adducts. Acetaldehyde also reacts with proteins producing stable aducts, NADH is metabolized and ATP increases produding Reactive Oxygen Species (ROS) when NADH is abundant and lipids when acetate acumulates, also ROS are produced by the enzyme CYP2E1 located in the microsome. Organ damage is produced initially by lipid acumulation in cells, cell necrosis which leads to a proliferative-inflamatory mildeu which then causes fibrotic deposition and general necrosis as in acute liver failure. The liver being the most affected since it expresses the CYP2E1 enzyme in higher proportion. Finally, phytochemical, toxicity and effectiveness in preclinical essays show that Overo Flower possess Commercial Potential and is applied to Routine, Catechin and Quercetine as a chromatographic fingerprint of any such commercial product.

Keywords: Xenobiotic, CYP2E1 enzyme, reactive oxygen species, necrosis, Cordia lutea Lam. flower, alcohol consumption, pathophysiology

Cite this Article: Vásquez EF. Alcohol Consumption, Organ Damage and Overo Flower (Cordia lutea Lam.): A Biochemical Approach. International Journal of Molecular Biotechnology. 2019; 5(2): 1–10p.