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Oral Delivery of Human Therapeutic Proteins: Current Status and Future Challenges

Abhay Kumar, Prafulla Kumar


Oral delivery of protein drugs is one of the highly attractive approach in today’s world, which leads to many attempts for development of such formulations. In spite of numerous attempts, however, no clinically impactful oral formulations have been developed, due to extremely low bioavailability of protein drugs. This is due to barriers related to poor absorption, poor permeation, and degradation in the gastrointestinal tract. So, the effective oral protein delivery needs to overcome these barriers. However numerous strategies have been made and explored for improving the bioavailability of orally administered proteins. Which consists of modification of protein drugs chemically, use of enzyme inhibitors, and use of unique formulation components, such as absorption enhancers and mucoadhesive polymers. This article examines the current technologies under development for oral protein delivery.

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