Protein-Protein Interaction (PPI) Network Analysis of Ficus racemosa Phytochemicals against Obesity

Abstract

Ficus racemosa is one of the common culinary herbs that has been extensively used as a crucial constituent of ayurvedic medicines. For exploring the comprehensive effects of its constituents in human at proteomic levels, we have reviewed all its known phytochemicals from different extracts of F. racemosa. The best phytochemical has been selected to compare the regulatory potential against various protein receptors with the help of Swiss Target Prediction. The interaction between these receptors has shown the best possible pathway affected by plant phytochemicals. The results have explained the effectiveness of the chemical compound against the lipid metabolic pathways. The interaction network has been prepared by using String analysis tool. We have reported around 15 receptors that has been affected by plant phytochemical. Out of which 9 were showed changes in lipid metabolic pathways. Thus, the study has concluded that the phytochemical isolated from the plant F. racemosa can be a promising drug against the obesity in humans.

Keywords: obesity, phytochemical, Ficus racemosa, anti-adipogenic activity, lipid metabolic pathway

Cite this Article: Kush Chopra, Sugandha Asthana. Protein-Protein Interaction (PPI) Network Analysis of Ficus Racemosa Phytochemicals against Obesity. International Journal of Computational Biology and Bioinformatics. 2019; 5(2): 16–21p