Grouping of Phylogeny, Pattern Profile Identification and Post- Translational Modifications in Cleavage Characterization of Cryptococcus neoformans var. grubii Serotype A Proteins
Abstract
roles in many cellular processes. In silico approach, individually proteins sequence
information and similarities with dissimilarities between the proteins in C. neoformans var.
grubii serotype A from the NCBI database. Relationships between the sequences were
compared by the protein identity, positives, length, identical sites, molecular weight, and
isoelectric point along with the multiple sequence alignment. Also, the amino acid
compositions of all the sequences have been investigated. Cleavage site identifications
(sulfinator), perfect identification of pattern profile in serotype A proteins of C. neoformans.
The online tools were used to this work is publicly accessible.
Full Text:
PDFReferences
K.J. Kwon-Chung, J.E. Bennett.
Cryptococcosis. Med Mycol. 1992;
–446p.
T.G.
Mitchell,
J.R.
Perfect.
Cryptococcosis in the era of AIDS-100
years after the discovery of
Cryptococcus
neoformans,
Clin
Microbiol Rev. 1995; 8: 515–48p.
J.W. Rippon. Cryptococcosis, Med
Mycol. 1988; 582–609p.
R.A. Clark, D. Greer, W. Atkinson,
G.T. Valainis, N. Hyslop. Spectrum of
Cryptococcus neoformans infection in
patients infected with human
immunodeficiency virus, Rev Infect
Dis. 1990; 12(5): 768–77p.
W.C. Chang, C. Tzao, H.H. Hsu, S.C.
Lee, K.L. Huang, H.J. Tung, C.Y.
Chen. Pulmonary cryptococcosis:
comparison
of
clinical
and
radiographic
characteristics
in
immunocompetent
and
immunocompromised patients, Chest.
; 129(2): 333–40p.
W. Sabiiti, R.C. May. Mechanisms of
infection by the human fungal
pathogen Cryptococcus neoformans,
Future Microbiol. 2012; 7(11): 1297–
p.
E.W. Bratton, N. Husseini, C.A.
Chastain, M.S. Lee, C. Poole, T.
Sturmer, J.J. Juliano, D.J. Weber,
J.R. Perfectet. Comparison and
temporal trends of three groups with
cryptococcosis: HIV-infected, solid
organ
transplant,
and
HIV-
negative/non-transplant, PloS One.
; 7(8): e43582p.
J. Aberg, P. WG. Cryptococcosis, In:
AIDS Therapy. R.M.H. Dolin, M.S.
Saag (eds.), 2002; 498–510p.
B.J. Park, K.A. Wannemuehler, B.J.
Marston, N. Govender, P.G. Pappas,
T.M. Chiller. Estimation of the
current global burden of cryptococcal
meningitis among persons living with
HIV/AIDS, AIDS. 2009; 23(4): 525–
p.
J.E. Bennett, W. Dismukes, R.J.
Duma, G. Medoff, M.A. Sande, H.
Gallis, J. Leonard, B.T. Fields, M.
Bradshaw, H. Haywood, Z.A.
McGee, T.R. Cate, C.G. Cobbs, J.F.
Warner, D.W. Alling. A comparison
of amphotericin B alone and
combined with flucytosine in the
treatment of cryptococcal meningitis,
N Engl J Med. 1979; 301: 126–31p.
J.P. Utz, J.S. Tynes, H.J. Shadomy,
R.J. Duma, M.M. Kannan, K.N.
Mason. 5-Fluorocytosine in human
cryptococcosis, Antimicrob Agents
Chemother. 1968; 8: 344–6p.
W.E. Dismukes, G. Cloud, H.A.
Gallis, T.M. Kerkering, G. Medoff,
P.C. Craven, L.G. Kaplowitz, J.F.
Fisher, C.R. Gregg, C.A. Bowles, S.
Shadomy, A.M. Stamm, R.B. Diasio,
L. Kaufman, S. Soong, W.C.
Blackwelder.
Treatment
of
cryptococcal
meningitis
with
combination amphotericin B and
flucytosine for four as compared with
six weeks, N Engl J Med. 1987; 317:
–41p.
D.C. Tanner, M.P. Weinstein, B.
Fedorciw, K.L. Joho, J.J. Thorpe,
L.B.
Reller.
Comparison
of
commercial kits for detection of
cryptococcal
antigen,
J
Clin
Microbiol. 1994; 32(7): 1680–4p.
A. Ikai. Thermostability and aliphatic
index of globular proteins, J
Biochem. 1980; 88(6): 1895–8p.
K. Guruprasad, B.V. Reddy, M.W.
Pandit. Correlation between stability
of a protein and its dipeptide
composition: a novel approach for
predicting in vivo stability of a
protein from its primary sequence,
Protein Eng. 1990; 4: 155–61p.
M. Flavio, G. Elisabeth, B. Amos, J.
Eva. The Sulfinator: predicting
tyrosine sulfation sites in protein
sequences, Bioinform Appl Note.
; 18(5): 769–70p.
H. Nicolas, B. Amos, B. Virginie, C.
Lorenzo, D.C. Edouard, S.L.G. Petra,
P. Marco, J.A.S. Christian. The
PROSITE database, Nucleic Acids
Res. 2006; 34: D227–30p.
DOI: https://doi.org/10.37628/ijcbb.v3i2.202
Refbacks
- There are currently no refbacks.