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Synthesis and Characterization of New Trimethoprim-Formazan Derivatives with Studying Them against Breast Cancer Cells
Abstract
Trimethoprim is considered one of the very important pharmaceutical drugs in the field of medical drugs, so we linked the trimethoprim drug with the formazan compound to increase its importance in treating cancerous tumors and reduce the size of the tumor and thus the importance of the prepared derivative increased more than the original medicine. In this study, we started from reaction of trimethoprim with hydrazine to yield hydrazo-trimethoprim which after that reacted with some different aldehydes to form imine-trimethoprim, then the last reaction with diazonium salt to form trimethoprim drug-formazan derivatives. All drug-derivatives examined by spectroscopic techniques such as (FT. IR, H1NMR, C13 HNMR) to improve chemical structures for active groups and environments, other measurements, and some other chemical characterizations such as melting point and thin layer chromatography (TLC), in addition to the biomechanical test (MTT) against Breast Cancer Cells.
Keywords
References
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