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Solid Dispersions of Curcumin

Tania Simran, A. Krishna Shailaja


Solid dispersion is dispersion of one or more active ingredients (hydrophobic) in an inert carrier (hydrophilic) at solid state. Curcumin is a naturally occurring, highly lipophilic, main pharmacological active phytochemical compound of turmeric and possesses diverse pharmacologic effects such as anti-inflammatory, antioxidant. Chemically, curcumin is a diarylheptanoid, belonging to the group of curcuminoids which are natural phenols responsible for turmeric's yellow color. Curcumin has limited aqueous solubility and poor bioavailability. Thus we are opting for solid dispersion technique in order to increase it solubility and bioavailability. The aim of present investigation is to prepare solid dispersion (SD) of curcumin using solvent evaporation method using PEG 4000 and PVP K 30. Six ratios (SD1, SD2, SD3, SD4, SD5, SD6) were prepared (SD1, SD2, SD3 using PVP K-30 and SD4, SD5, SD6 using PEG 4000). The PVP K-30 ratios showed increased solubility (SD1—0.79%, SD2–5.40%, SD3 6.48%) when compared to pure curcumin (0.52%) and the ratios containing PEG 4000(SD4 0.24%, SD5 0.28%, SD6 0.47%).


Curcumin, solid dispersion technique, PEG 4000, PVP K-30.

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